Students who graduate with a Biology major are exposed to traditional and laboratory courses and are encouraged to participate in undergraduate research. USF is a partner institution of the South Dakota Biomedical Research Infrastructure Network (BRIN) which provides students with an opportunity to be involved in research projects on campus.

BRIN has been funded by the National Center for Research Resources (NIH) since 2001. They have several Cores (proteomics, genomics, bioinformatics and west core) with about 80 members.